The study of long term effects on the young infected by Toxoplasma gordii during mother's pregnancy / 临床儿科杂志

ABSTRACT

Objective To explore the long term effects of Toxoplasma gondii infection during pregnancy on memory and learning ability of her child and provide therapeutic strategy. Methods Middle-school students selected according to their mother's pregnant record of Toxoplasma gondii IgM, CAg were divided into three groups healthy group (negative Toxoplasma gondii IgM, CAg in both mother's blood and umbilical cord blood), non infected group (positive in mother's blood, but negative in umbilical cord blood), infected group (positive in both mother's blood and umbilical cord blood). Infected group was subdivided into treated group (with special training) and untreated group. All objects wereevaluated their memory and learning ability with Mini-Mental State Examination (MMSE) , Tower of Hanoi (TOH-1-TOH-d-TOH-s-TOH-2) and Wisconsin Card Sorting Test (WCST-1-WCST-d-WCST-s-WCST-2). Results The scores in items about calculation, recall and total of MMSE were significantly lower in untreated group than that in non infected group (P 0.05). Conclusions Toxoplasma gondii infection during pregnancy damages the infected children's mental development. Early cognitive rehabilitation is very important for the infected children.