Research of decanoyl acetaldehyde on anti-inflammation and anti-atherosclerosis / 中成药
Chinese Traditional Patent Medicine
; (12): 26-30, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-433198
Responsible library:
WPRO
ABSTRACT
AIM:
To study the effect of decanoyl acetaldehyde against atherosclerosis and the relative mechanisms in rats.METHODS:
Rats were randomly assigned into 5 groups,That were the control,model,low and high dose of decanoyl acetaldehyde and ibuprofen groups.The model rats were intraperitoneally injected with 600 000 IU/kg vitamine Ds and intragastricly administrated with high-fat emulsion 10 mL/( kg·d) for 70 days.At the same time,the model rats treated with drugs were orally given 39 mg/( kg·d),78 mg/( kg·d) decanoyl acetaldehyde and 144 mg/( kg·d) ibuprofen suspension respectively.After 70 days,the rats were euthakilled,and the serum level of TC,LDL-C,HDL-C/LDL-C ,TNF-α,IL-1β,IL-6,IL-10,the expression of NF-κB in rat aorta and the pathological change in aorta were measured.RESULTS:
Decanoyl acetaldehyde could lower the serum level of TC,LDL-C,TNF-α,IL-1β and IL-6.It increased the level of IL-10 and the ratio of HDL-C/LDL-C,inhibited the expression of NF-κB and reduced the thickness of the artery wall.CONCLUSION:
Decanoyl acetaldehyde has an effect on anti-atherosclerosis.The mechanism may be related with inhibiting inflammation and lowering serum lipid.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
2010
Document type:
Article