Inlfuence of transport protein gene polymorphisms on the effects and toxicity of high-dose methotrexate in child-hood acute lymphoblastic leukemia / 临床儿科杂志
Journal of Clinical Pediatrics
; (12): 733-736, 2013.
Article
in Zh
| WPRIM
| ID: wpr-433419
Responsible library:
WPRO
ABSTRACT
Objectives To investigate the inlfuence of polymorphisms of SLC19A1 80G>A, MDR1 exon26C>T and MDR1 exon21G>T/A on curative effect and adverse reaction of high-dose methotrexate in patients with acute lymphoblastic leukemia. Methods MALDI-TOF-MS technique was used to detect the polymorphisms of SLC19A1 80G>A, MDR1 exon 26C>T and MDR1 exon21G>T/A in 108 patients with acute lymphoblastic leukemia (ALL). The relationship of genetic polymorphism, survival rate and toxicity was analyzed. Results The 36-month event-free survival was not related to any polymorphisms of MDR1 and SLC19A1. Patients with mutant types of MDR1 exon26C>T and MDR1 exon21G>T/A showed a much higher MTX plasma levels at 24 hours and higher incidence of hepatic injury (PT, MDR1 exon21G>T/A has a large inlfuence on hepatic toxicity and plasma concentra-tions of MTX.
Full text:
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Database:
WPRIM
Language:
Zh
Journal:
Journal of Clinical Pediatrics
Year:
2013
Document type:
Article