DETECTION OF THE LEVELS OF THE IFN-γ AND TNF-α IN SERUM OF THE PATIENES WITH THE DENGUE VIRUS INFECTION AND ITS CLINICAL SIGNIFICANCE / 中国人兽共患病学报
Chinese Journal of Zoonoses
; (12): 19-21, 2001.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-433865
Responsible library:
WPRO
ABSTRACT
AimTo study the effect of interferon gamma( IFN-γ) and tumor necrosis factor alpha(TNF-α) in the immune pathogenesis of dengue virus infection. Method The serum levels of IFN-γ and TNF-α were measured with emzyme linked immunosorbent assay (ELISA) method in 30 cases of the patients with the dengue virus infection in Guangzhou district. The results were treated with t-test of two sample mean. ResultsThe serum levels of IFN-γ and TNF-α in patients with the dengue virus infection were much higher than healthy controls( P < 0.05、 P < 0.01 ). IFN-γ was detectable on the first day of postinfection. Level of IFN-γ reached their peaks on the second day, then declined . The level of TNF-α had an obvious rise from the second day and reached their peaks on the third day, then declined. ConclusionThe data suggest that the IFN-γ and TNF-α may play an important role in the dengue virus pathogenicity and immunity.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Dengue
/
Neglected Diseases
Database:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Zoonoses
Year:
2001
Document type:
Article