Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebellum of the nNOS knock-out(-/-) mice / 대한해부학회지
Anatomy & Cell Biology
; : 64-71, 2010.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-43656
Responsible library:
WPRO
ABSTRACT
Nitric Oxide (NO) actively participates in the regulation of neuronal intracellular Ca2+ levels by modulating the activity of various channels and receptors. To test the possibility that modulation of Ca2+ buffer protein expression level by NO participates in this regulatory effect, we examined expression of calbindin-D28k, calretinin, and parvalbumin in the cerebellum of neuronal NO synthase knock-out (nNOS(-/-)) mice using immunohistochemistry. We observed that in the cerebellar cortex of the nNOS(-/-) mice, expression of calbindin-D28k and parvalbumin were significantly increased while expression of calretinin was significantly decreased. These results suggest another mechanism by which NO can participate in the regulation of Ca2+ homeostasis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
S100 Calcium Binding Protein G
/
Calcium-Binding Proteins
/
Immunohistochemistry
/
Cerebellar Cortex
/
Cerebellum
/
Calcium
/
Nitric Oxide Synthase
/
Homeostasis
/
Neurons
/
Nitric Oxide
Limits:
Animals
Language:
English
Journal:
Anatomy & Cell Biology
Year:
2010
Document type:
Article