The effects of exenatide on insulin sensitivity in type 2 diabetics patients / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 2924-2926, 2013.
Article
in Zh
| WPRIM
| ID: wpr-436758
Responsible library:
WPRO
ABSTRACT
Objective To investigate the effects of exenatide on insulin sensitivity in type 2 diabetics.Methods 42 diabetics of secondary failure of sulfonylurea were recruited in the study,and were distinguished to the exenatide group and the glargine group.Besides being treated with diabetic conventional and original treatments,the two groups were given respectively exenatide before breakfast and dinner,or glargine before sleeping by subcutaneous injection for five weeks.Insulin sensitivity of the two groups was elevated by euglycemic-hyperinsulinemic clamps before and after treatment.The metabolic indices were determined.Results Compared with baseline levels,after treatment the glucose metabolic rate was improved [(5.12 ± 0.35) vs (2.94 ± 0.41)] mg · kg-1 · min-1,P < 0.05],the BMI and HMOA-IR was reduced[4.51 (1.32 ~ 6.12) vs 1.96 (1.32 ~ 6.12)],in the exenatide groups,which were better than the glargine group (P < 0.05).Gastrointestinal adverse reactions,which were tolerable and decreased,were appeared in nearly 31.42% of subjects.There were no severe hypoglycemic events in both groups.Conclusion Short-term treatment with exenatide could improve the insulin sensitivity of type 2 diabetics.
Full text:
1
Database:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2013
Document type:
Article