Non-Vitamin K Oral Anticoagulants in Stroke Patients: Practical Issues / 대한뇌졸중학회지
Journal of Stroke
; : 138-145, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-43714
Responsible library:
WPRO
ABSTRACT
Non-vitamin-K oral anticoagulants (NOACs) represent a major advance in the prevention of stroke in patients with atrial fibrillation (AF), offering a similar, if not superior, efficacy and safety profile and several practical advantages over oral vitamin K antagonists (VKAs). The rapid onset of action of the NOACs, their relatively short half-live, and the availability of specific reversal agents may be advantageous when managing acute ischemic strokes, and in the post-stroke, post-transient ischemic attack, and post-intracranial hemorrhage settings. In this review article, we offer practical guidance on the use of NOACs in these settings, focusing on managing the acute event and on initiating or resuming anticoagulation for secondary prevention. We also assess the use of NOACs to prevent stroke and bleeding in patients with AF who have chronic kidney disease, are elderly, or cognitively impaired, and we offer guidance on optimizing the use of NOACs and VKAs in these patient groups in the absence of evidence-based guidelines.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Atrial Fibrillation
/
Vitamin K
/
Ischemic Attack, Transient
/
Stroke
/
Renal Insufficiency, Chronic
/
Secondary Prevention
/
Hemorrhage
/
Anticoagulants
Type of study:
Practice guideline
Limits:
Aged
/
Humans
Language:
English
Journal:
Journal of Stroke
Year:
2016
Document type:
Article