Preoperative Erythropoietin Administration in Patients With Prostate Cancer Undergoing Radical Prostatectomy Without Transfusion
Korean Journal of Urology
; : 102-105, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-43769
Responsible library:
WPRO
ABSTRACT
PURPOSE:
In this study, we administered erythropoietin preoperatively to patients who underwent open radical prostatectomy without transfusion to increase their hemoglobin levels and investigated the efficacy of this procedure. MATERIALS ANDMETHODS:
We evaluated 62 patients who underwent open radical prostatectomy performed by the same surgeon between June 2005 and January 2011. The 22 patients who refused transfusion were assigned to group 1; the patients who accepted transfusion were assigned to group 2. Before surgery, we administered erythropoietin beta to group 1 patients whose hemoglobin levels were <12 g/dL and retrospectively compared the clinical data of the two groups. We used the t-test and the chi-square test for statistical analysis.RESULTS:
Mean preoperative hemoglobin levels in group 1 after erythropoietin administration (14.5 g/dL) were significantly higher than those in group 2 (13.59 g/dL, p=0.003). Moreover, the difference in the mean hemoglobin levels before and after surgery for group 1 patients (3.55 g/dL) significantly exceeded that for group 2 patients (2.08 g/dL, p=0.000). Additional analysis revealed no statistically significant differences in perioperative complications between the groups.CONCLUSIONS:
Preoperative erythropoietin administration increased the safety margin of hemoglobin levels, and this strategy worked sufficiently well in our experience.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatectomy
/
Prostatic Neoplasms
/
Blood Transfusion
/
Retrospective Studies
/
Erythropoietin
/
Jehovah's Witnesses
/
Bloodless Medical and Surgical Procedures
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Urology
Year:
2014
Document type:
Article