Caspase-11, the Main Executioner in Non-canonical Inflammasome
Journal of Bacteriology and Virology
; : 169-171, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-43861
Responsible library:
WPRO
ABSTRACT
Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11 rather than caspase-1 is the main offender involved in sepsis. Hence, caspase-11 plays an essential pro-inflammatory role in innate immune response to bacterial infections.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Cholera
/
Neglected Diseases
/
Zoonoses
Database:
WPRIM (Western Pacific)
Main subject:
Bacterial Infections
/
Vibrio cholerae
/
Cholera Toxin
/
Sepsis
/
Citrobacter rodentium
/
Escherichia coli
/
Criminals
/
Immunity, Innate
Limits:
Humans
Language:
English
Journal:
Journal of Bacteriology and Virology
Year:
2012
Document type:
Article
