Mitogen-activated protein kinases and morphine tolerance / 基础医学与临床

ABSTRACT

The MAPKs activation pathway consists of three protein kinases in activation sequenceMAPKs kinase kinases (MKKKs)→,MAPKs kinases (MKKs)→MAPKs and four pathwaysextracellular signal-regulated kinase (MAPK~(ERK)),C-JUN N-terminal kinase (MAPK~(JNK)),MAPK~(P38) and MKKS/MAPK~(ERK5) activation pathways.It has been proved that MAPKs(ERK,JNK and P38) are acvtivated in the progress of morphine tolerance.Inhibitors of any element of MAPKs activation pathway may function as a potential clinical medicine for morphine tolerance.