Role of Let-7 family in pathogenesis of Alzheimer disease / 国际生物医学工程杂志
International Journal of Biomedical Engineering
; (6): 307-310, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-442254
Responsible library:
WPRO
ABSTRACT
Alzheimer disease (AD) is a fatal neurodegenerative disorder,and the most common cause of dementia in the elderly.Accumulated evidences in AD research suggest that alterations in the microRNA (miRNA) network could contribute to risk for the disease.As the second discovered miRNA,Let-7 has an important effect on cell proliferation,differentiation,apoptosis,immune response,tumorigenesis,metastasis,and so on.We review in this article the role of Let-7 family in the pathogenesis of AD to provide a strong basis for future research aimed at understanding the potential contribution of miRNAs to AD pathophysiology.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
International Journal of Biomedical Engineering
Year:
2013
Document type:
Article