The Mechanism of Anti-Epileptogenesis by Levetiracetam Treatment is Similar to the Spontaneous Recovery of Idiopathic Generalized Epilepsy during Adolescence
Psychiatry Investigation
; : 844-850, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-44337
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant neurogenesis and extended axon sprouting. Once hyperexcitation of the neural network occurs, spontaneous seizures or epileptogenesis develops. This study investigated whether the anti-epileptogenic effect of levetiracetam is due to its alternate apoptotic activity.METHODS:
Adult male Noda epileptic rats were treated with levetiracetam or vehicle control for two weeks. mRNA quantification of Bax, Bcl-2 and GAPDH expression were performed from prefrontal cortex and hippocampus tissue samples.RESULTS:
The levetiracetam-treated group showed a significant increase of Bax/Bcl-2 mRNA expression ratio in the prefrontal cortex than the control group, but no change in the Bax/Bcl-2 mRNA expression ratio in hippocampus.CONCLUSION:
Idiopathic generalized epilepsy including childhood absence epilepsy develop at childhood and recover spontaneously during adolescence. The aberrant neural excitable network is pruned by a neural-maturing action. This study suggests the mechanism of acquired anti-epileptogenesis by levetiracetam treatment may be similar to spontaneous recovery of idiopathic generalized epilepsy during adolescence.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Epilepsy
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Environmental Health
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Neonatal Healthcare
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Noncommunicable Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Seizures
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Axons
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RNA, Messenger
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Cell Death
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Epilepsy, Generalized
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Epilepsy, Absence
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Prefrontal Cortex
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Apoptosis
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Brain-Derived Neurotrophic Factor
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Neurogenesis
Limits:
Animals
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Humans
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Male
Language:
English
Journal:
Psychiatry Investigation
Year:
2017
Document type:
Article