Meta-analysis on the prevalence rate of osteoporosis in the middle-aged and elderly in China / 中国组织工程研究

ABSTRACT

BACKGROUND:Investigation regarding epidemiologic features of osteoporosis in many areas of China has been much reported. However, studies regarding large samples and multicenter in China have been rarely reported. It is said that published papers cannot give a good description about the epidemiologic features of osteoporosis at present. OBJECTIVE:To understand the epidemiologic features of osteoporosis by evaluating the data on the epidemiology of osteoporosis in the middle-aged and elderly in China. METHODS:Meta-analysis was used to evaluate the data extracted from 2000-2013 published papers on the epidemiology of prevalence rates of osteoporosis in the middle-aged and elderly in China. The prevalence rates of osteoporosis were extracted from middle-aged and elderly populations aged above 40 years, with 10 years for a group. The studies were col ected and analyzed using Stata 12.0. RESULTS AND CONCLUSION:Thirty two articles were included with a total of 58 254 people (26 844 males and 31 410 females). The total prevalence rate of osteoporosis at the age above 40 years in China was 13.2%. The prevalence rate of males was 11.8%and that of females was 14.2%, and there was a significant difference between males and females (P<0.05). With aging, the prevalence rate of osteoporosis is increasing both in males and females, which increases gradual y in males but significantly elevates in females over 50 years old. In China, the detection rate of lumbar osteoporosis is higher in the northern region than the southern region, probably because of more heavy physical activities in the northern region;whereas, the detection rate of Ward’s osteoporosis is higher in the southern region than the northern region. In the recent 5 years, the prevalence rate of osteoporosis is significant increased in males and reduced in females compared with 5 years ago. These findings suggest that osteoporosis in Chinese is common and extensively distributed, and it is important to propagate knowledge of osteoporosis and prevent osteoporosis.