Role of calcium signaling in neoplasms invasion and migration / 国际肿瘤学杂志
Journal of International Oncology
; (12): 161-164, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-444168
Responsible library:
WPRO
ABSTRACT
Intracellular calcium is one of the crucial signalings that modulate various physiological and pathological processes.Abnormal calcium signaling is closely associated with invasion and migration of neoplasms.Calcium regulates focal adhesion turnover,cytoskeletal reorganization and other processes about tumor cell movement through contacting with multiple downstream proteins,such as calpain,PYK2 and S100 protein family.Several calcium entry channels including store-operated calcium channels and transient receptor potential channels participate in the invasion and migration of tumor cells.Pathological calcium signaling may be a potential target in anti-invasion and anti-migration therapy.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2014
Document type:
Article