Optimal dose and volume for postoperative radiotherapy in brain oligometastases from lung cancer: a retrospective study
Radiation Oncology Journal
; : 153-162, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-44437
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To evaluate intracranial control after surgical resection according to the adjuvant treatment received in order to assess the optimal radiotherapy (RT) dose and volume. MATERIALS ANDMETHODS:
Between 2003 and 2015, a total of 53 patients with brain oligometastases from non-small cell lung cancer (NSCLC) underwent metastasectomy. The patients were divided into three groups according to the adjuvant treatment received whole brain radiotherapy (WBRT) ± boost (WBRT ± boost group, n = 26), local RT/Gamma Knife surgery (local RT group, n = 14), and the observation group (n = 13). The most commonly used dose schedule was WBRT (25 Gy in 10 fractions, equivalent dose in 2 Gy fractions [EQD2] 26.04 Gy) with tumor bed boost (15 Gy in 5 fractions, EQD2 16.25 Gy).RESULTS:
The WBRT ± boost group showed the lowest 1-year intracranial recurrence rate of 30.4%, followed by the local RT and observation groups, at 66.7%, and 76.9%, respectively (p = 0.006). In the WBRT ± boost group, there was no significant increase in the 1-year new site recurrence rate of patients receiving a lower dose of WBRT (EQD2) <27 Gy compared to that in patients receiving a higher WBRT dose (p = 0.553). The 1-year initial tumor site recurrence rate was lower in patients receiving tumor bed dose (EQD2) of ≥42.3 Gy compared to those receiving <42.3 Gy, although the difference was not significant (p = 0.347).CONCLUSIONS:
Adding WBRT after resection of brain oligometastases from NSCLC seems to enhance intracranial control. Furthermore, combining lower-dose WBRT with a tumor bed boost may be an attractive option.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Appointments and Schedules
/
Radiotherapy
/
Recurrence
/
Brain
/
Retrospective Studies
/
Carcinoma, Non-Small-Cell Lung
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Radiotherapy, Adjuvant
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Metastasectomy
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Lung
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Lung Neoplasms
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2017
Document type:
Article