Discussion on ethical issues in experimental rats of fentanyl combined with midazolam in anesthesia / 中华医学科研管理杂志

ABSTRACT

Objective To analyze the mechanism of fentanyl combines midazolam,by comparison with some of the commonly used anesthetic method to determine in the ethical advantages of anesthesia.Methods 45 rats were randomly divided into three groups,Group A1％ anesthetized by intraperitoneal injection of sodium pentobarbital 40 mg/kg; Group B5 ％ ketamine 120 mg/kg intraperitoneal injection; Group Cmidazolam 5 mg/kg + fentanyl 0.05 mg/kg Last intravenous anesthesia.Observe the effects of anesthesia.Results The rats which are used of fentanyl conbines midazolam anesthesia,the onset of anesthesia time0.02 ± 0.03 min,maintenance of anesthesia time89.73 ± 22.59 min,the the narcotic operation time1.51 ± 0.30 min,the success of anesthesia cases15 cases.Conclusions Fentanyl combines midazolam compared with the currently used method of anesthesia,the advantages of the more prominent,it has significant improvement and protection about the security,utilization and recovery ethics in experimental rats.