Electrospinning technology in tissue engineering:how far is it from the successful application in biomedicine? / 中国组织工程研究

ABSTRACT

BACKGROUND:Electrospinning preparation for the tissue engineering scaffold materials is an extremely promising technology. OBJECTIVE:To review the progress of electrospinning technology in different fields and its main problems in the current application. METHODS:We searched Medline and CNKI databases for articles published from 2000 to 2013 using the keywords of“electrospinning, tissue engineering”in English and Chinese. RESULTS AND CONCLUSION:The structure of non-woven cloth materials made by this technology is similar to the extracel ular matrix, which has high surface area and control able mechanical properties. Electrospinning materials have been widely applied in the tissue engineering field, especial y in the biodegradable materials and high biocompatibility molecular polymer synthesis process. Electrospinning has been developed rapidly in tissue engineering applications, especial y in the choice of materials or electrospinning technique combined with different technologies. Different morphological structures and properties of the materials can be wel combined by using electrospinning technology. A series of new polymers were successful y incorporated into a tissue engineering scaffold as the matrix for cel proliferation and regeneration, but there are some important issues to be solved, including how to control the interaction between the scaffold and the biological system that is to achieve the infiltrative growth of cel s, how to control the pore size, mechanical properties and toxicity. This technology clinical y applied in biomedicine stil requires further research, especial y in vivo studies.