Clinical effects of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: a Meta-analysis / 国际外科学杂志

ABSTRACT

Objective To compare clinical effects of appendicectomy and conservative treatment of uncomplicated acute appendicitis.Methods Searched The Cochrane library,Medline,Pubmed,Embase,CBM,CNKI,VIP and Wan Fang database in any language.RCTs that compared conservative treatment with appendicectomy in patients with uncomplicated acute appendicitis were included from January 1983 to May 2013 and qualities of the trials were evaluated.Statistic analyses were carried out using RevMan 5.1 soft-ware.Results Four randomized trials met our inclusion criteria (821partiCIpants).Antibiotics compared with appendicectomy resulted in similar outcomes with regards to the incidence of complicated appendicitis (RR0.89,95％ CI0.29-2.68) and intra-abdominal infection(RR0.54,95％ CI0.13-2.35).Antibiotics carries a lower risk of complications (RR 0.46,95％ CI0.32-0.67),but requires more length of hospital stay (Mean Difference 0.52,95％ CI0.16-0.88).Conclusions The effect of conservative treatment is safe and effective.But the recurrent uncomplicated appendicitis recommends operation.