Expression of STAT3 in children with focal cortical dysplasias type IIIa / 临床儿科杂志
Journal of Clinical Pediatrics
; (12): 859-862, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-453877
Responsible library:
WPRO
ABSTRACT
Objectives To detect the expression of STAT3 in children with FCD (focal cortical dysplasias) type IIIa. Methods The expression of STAT3 and P-STAT3 (ser727) were determined in temporal lobe specimens from 26 children with FCD type IIIa and from 5 normal control by immunohistochemistry, immunolfuorescence and Western blot. Results The expression of P-STAT3 (ser727) was obviously higher in FCD type IIIa than in control group. P-STAT3 (ser727) was located mainly in the nucleus of astrocytes. Conclusions Activated STAT3 might contribute to the patholgenesis of FCD type IIIa by mediating proliferation of astrocytes.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Pediatrics
Year:
2014
Document type:
Article