Abnormal grey matter changes in first-episode antipsychotic-na?ve patients with adolescent-onset schizophrenia / 中国神经精神疾病杂志

ABSTRACT

Objective To investigate gray matter structural damage in first-episode antipsychotic-na?ve patients with adolescent-onset schizophrenia. Methods Twenty-six patients with schizophrenia and 26 healthy controls were scanned by using GE 3.0T magnetic resonance imaging in order to explore brain gray matter volume (GMV) changes with registration techniques based on the latest morphological deformation field theory. The correlation of gray matter volume abnormalities with clinical severity was also analyzed. Results Compared with healthy controls, patients with adoles-cent-onset schizophrenia showed significant reduction in GMV in the left parietal lobe, parahippocampal gyrus and right cerebellar pyramis. GMV of the left parahippocampal gyrus is significantly correlated with PANSS paranoid scores (r=-0.49, P=0.02). Conclusions There is structural abnormality in GM in parahippocampal-parietal-cerebellar in pa-tients with adolescent-onset schizophrenia and the severity of paranoid symptoms is related to the reduced GMV in the left parahippocampal gyrus.