Progress of hyperhomocysteinemia hazard and pathogenesis / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1205-1208, 2014.
Article
in Zh
| WPRIM
| ID: wpr-456662
Responsible library:
WPRO
ABSTRACT
Homocysteine ( Hcy) is an independent risk factor for a variety of diseases and closely related to cardiac-cerebralvascu-lar diseases, neurological diseases, diabetes and diabetic com-plications. High homocysteine levels can significantly increase the recurrence risks of cardiac-cerebralvascular events and stroke in patients with stroke, leading to high all-cause mortality. The risk of Alzheimer’s disease is increased by 1. 8 fold when the concentration of Hcy is over 14 μmol·L-1 . For each 5 μmol· L-1 increase in plasma Hcy in diabetes patients, the mortality rate increases by 5 fold in the next five years. High Hcy triggers the pathogenesis of diseases via multiple mechanisms including oxidative stress, lesions of vascular endothelial cells, prolifera-tion of vascular smooth muscle cells, dysfunction of coagulation and lipid metabolism and genomic hypomethylation etc.
Full text:
1
Database:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2014
Document type:
Article