Analysis of risk factors for Parkinson's disease in 91 patients in Shanxi: a case-control study / 中华老年医学杂志

ABSTRACT

Objective To analyze the possible risk factors for Parkinson's disease (PD),and to provide clues to its etiology and prevention.Methods A matched case-control study,including 91 cases of PD and 364 controls,was carried out in Shanxi Provincial People's Hospital.Subjects completed an interviewer administered questionnaire about some putative risk factors.Multivariable conditional Logistic regression model was used to analyze the associated factors for PD.SAS 8.0 was used to analyze the data.Results 6 risk factors were found significantly associated with PD.The odds ratio (OR) of Parkinson's disease was 5.421 (95％CI:1.272-23.103) for family history,3.330 (95％CI:1.268-8.741) for rural living more than 10 years,2.495 (95％CI:1.044-5.961) for maternal smoking during pregnancy,1.607 (95％ CI:1.224-2.112) for maternal age more than 37 years,3.673 (95％CI:1.766 7.643) for history of drinking alcohol,2.147 (95％CI:1.279 3.602) for less physical exercising.Conclusions PD is a disease affected by the interaction of genetic and environmental factors,and the risk factors should be intervened selectively.