Effect of Saikokeishito, a Kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts / 中西医结合学报
Journal of Integrative Medicine
; (12): 495-503, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-457144
Responsible library:
WPRO
ABSTRACT
Saikokeishito (TJ-10) is a Kampo (traditional Japanese herbal) medicine, clinically used for hundreds of years in East Asia. Among its various mechanisms elucidated so far, TJ-10 inhibits the production of transforming growth factor-β1 (TGF-β1) and development of pancreatic fibrosis in vivo. Oxidative damage of normal human dermal fibroblasts (NHDFs) in the corium is a cause of human dermal senescence. Our aim was to determine whether TJ-10 protects NHDFs from premature senescence by hydrogen peroxide (H₂O₂).
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
English
Journal:
Journal of Integrative Medicine
Year:
2014
Document type:
Article