SRSF2 gene mutation and myeloid malignancies / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12): 2289-2293, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-457500
Responsible library:
WPRO
ABSTRACT
[ ABSTRACT] The splicing factors were characterized for their crucial roles in pre-mRNA splicing of eukaryons. SRSF2 is a member of the SR protein family which is one of the most common splicing factors, and it is believed to be a key element in pre-mRNA splicing, mRNA transcription, regulation of the DNA stability and cell proliferation.SRSF2 gene mutation is detected frequently in myeloid malignancies ( like MDS and CMML) and may be associated with the phenotype and prognosis of these malignancies.The paper makes a review for the latest research progression on SRSF2 gene mutation and its relationship with myeloid malignancies.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2014
Document type:
Article