The effects of scutellarin on Bcl-2 and Bax expression in human tongue squamous carcinoma Tca-8 1 1 3 cells / 实用口腔医学杂志

ABSTRACT

Objective:To investigate the effects of scutellarin on Bcl-2 and Bax expression in human tongue squamous carcinoma Tca-8113 cell.Methods:Tca8113 cells were treated with 80,120 and 160μg/ml scutellarin for 48 h respectively.Immunocytochem-istry method and RT-PCR were applied to observe the expression of Bcl-2 and Bax protein and mRNA in the cells.Results:With the increase of scutellarin concentration,Bcl-2 protein and mRNA decreased(P<0.05),Bax protein and mRNA increased(P<0.05). Conclusion:Scutellarin may downregulate Bcl-2 expression and upregulate Bax expression in Tca-8113 cells.