Effect of amlodipine combined with atorvastatin on blood vessels function of hypertension patients with dys-lipidemia / 中国基层医药

ABSTRACT

Objective To explore the degree of the improvement for hypertension patients with dyslipidemia by amlodipine combination atorvastatin treatment, and analyze the influence on vascular function.Methods 186 hypertension patients with dyslipidemia were selected.According to random number table,they were divided into the control group (91 cases) and the treatment group (95 cases),the control group was given amlodipine treatment,the treatment group was given Atorvastatin Calcium Tablets on the basis of the control group.The main indexes were the difference of systolic and diastolic blood pressure before and after the treatment,and high resolution detection of carot-id artery intima media thickness ( IMT) and carotid plaque area by color Doppler ultrasoundand.Serum total choles-terol ( TC) ,triglyceride ( TG) ,low density lipoprotein cholesterol ( LDL-C) and blood viscosity,hematocrit,erythro-cyte aggregation index were compared the change degree before and after treatment.Results The differences of pre and post-treatment on the systolic and diastolic blood pressure of the treatment group were (25.76 ±4.81)mmHg and (12.40 ±3.66)mmHg,higher than those of the control group,the difference was statistically significant (t=9.48, 8.76,all P<0.05).The differences of pre and post-treatment on IMT and plaque area of the treatment group were (0.10 ±0.11) mm and (0.33 ±0.14) mm2,higher than those of the control group,there was statistical significant differences (t=5.40,5.93,all P<0.05).The differences of pre and post-treatment on TC,TG and LDL-C of the treatment group were(1.06 ±0.38)mmol/L,(0.76 ±0.31)mmol/L and (0.58 ±0.20)mmol/L,higher than those of the control group,the difference was statistically significant (t=6.85,6.13,7.02,all P<0.05).The differences of pre and post-treatment on plasma viscosity,whole blood viscosity,hematocrit and erythrocyte of the treatment group were (0.36 ±0.08)Pa· s,(0.51 ±0.14)Pa· s,(0.41 ±0.12) and (0.31 ±0.12),higher than those of the con-trol group,the difference was statistically significant (t=5.81,4.97,5.11,6.86,all P<0.05).Conclusion The combination of amlodipine and atorvastatin on hypertension patients with dyslipidemia could reduce blood pressure and blood fat significantly,improve blood rheology,which has a good protective effect on vascular function.