Thalassemia gene detection and investigate in people of child-bearing age in Meizhou / 国际检验医学杂志

ABSTRACT

Objective To investigate the prevalence of thalassemia gene carried by child-bearing age people in Meizhou area. Methods Use regular blood tests and hemoglobin electrophoresis to screen the suspect thalassemia patients in couples of child-bearing age who underwent premarital examination or pregnancy check in the hospital.Samples with positive results were tested by using hybridization reverse dot blot to make a definite diagnosis of thalassemia.Results 208 samples were screened to be positive, among which there were 64 cases ofα-thalassemia carrier(30.67%),32 cases ofβ-thalassemia carrier(15.38%),3 case of combina-tion thalassanemia(1.92%).Conclusion The study may provide a reference for taking effective measures to prevent the birth of children with thalassemia.