Study on the relation of disease classification and osteoporosis in patients with Chronic obstructive pulmonary disease / 中国基层医药

ABSTRACT

Objective To study the relation of disease classification and osteoporosis in patients with chronic obstructive pulmonary disease,and to provide a theoretical basis for secondary osteoporosis.Methods A retrospective analysis of clinical data of 126 patients with COPD from January 2012 to December 2014 was made.50 non-COPD patients were included as control group,the pulmonary function and BMD of the femoral neck,trochanter,Ward Dis-trict were detected.And according to FEV1 , all patients were divided into mild pulmonary dysfunction group ( n=31),moderate pulmonary dysfunction group (n=54) and severe pulmonary dysfunction group (n=41);the rate of osteoporosis were measured in COPD group and non-COPD group,the difference of BMD were compared in patients with different pulmonary injury.Results ( 1 ) There were 45 cases of osteoporosis in 126 patients with COPD, accounting for 35.7%, 22 cases of osteopenia, accounting for 17.5%.There were 9 cases of osteoporosis in 50 patients with non-COPD,accounting for 18%,the incidence of osteoporosis were statistically different in COPD group and non-COPD group,χ2 =5.281,P<0.05.(2)The BMD of the femoral neck in mild COPD group,moderate COPD group,severe COPD group and non-COPD group were (0.74 ±0.11) g/cm,(0.66 ±0.08) g/cm,(0.56 ± 0.05)g/cm and (0.94 ±0.10) g/cm,the BMD of trochanter were respectively (0.71 ±0.12) g/cm,(0.63 ± 0.07)g/cm,(0.56 ±0.05)g/cm and (0.95 ±0.08)g/cm,the BMD of Ward District were (0.88 ±0.14)g/cm, (0.72 ±0.10)g/cm,(0.61 ±0.07)g/cm and (0.96 ±0.09)g/cm respectively,which were statistically significant (F=7.557,6.852,7.432,all P<0.01).The BMD of the femoral neck,trochanter,Ward District in COPD group were significantly less than non-COPD,and the more severe of pulmonary dysfunction,the more decreases of bone density.(3) The FEV1% in osteoporosis group,osteopenia group,normal BMD group were respectively (59.0 ±8.7)%,(77.7 ±7.6)% and (49.4 ±15.8)%;the FVC% were (77.8 ±28.8)%,(88.9 ±38.4)%,(73.8 ± 21.1)%;the FEV1/FVC were (66.5 ±20.6)%,(59.8 ±24.2)%,(34.1 ±3.6)%(F=9.554,5.556,7.487,all P<0.01),Conclusion There were a certain correlation between BMD and lung function.Osteoporosis is one of the extrapulmonary effects in elder COPD patients.So BMD should be regularly monitored for helping for early prevention and treatment of osteoporosis and development in osteoporosis,and improving lung function and clinical efficacy.