Acute pancreatitis associated with pegylated interferon-alpha-2a therapy in chronic hepatitis C
Clinical and Molecular Hepatology
; : 168-171, 2016.
Article
in En
| WPRIM
| ID: wpr-46327
Responsible library:
WPRO
ABSTRACT
Chronic hepatitis C virus (HCV) infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Combination therapy of pegylated interferon-alpha (PEG-IFN-α) and ribavirin (RBV) is a current standard treatment for chronic HCV infection in Korea, which has considerable adverse effects. Acute pancreatitis is a rare complication of PEG-IFN-α administration. We report a case of a 62-year-old female who experienced acute pancreatitis after 4 weeks of PEG-IFN-α-2a and RBV combination therapy for chronic HCV infection. The main cause of the acute pancreatitis in this case was probably PEG-IFN-α rather than RBV for several reasons. A few cases have been reported in which acute pancreatitis occurred during treatment with PEG-IFN-α-2b. This is the first report of acute pancreatitis associated with PEG-IFN-α-2a in Korea.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Antiviral Agents
/
Pancreatitis
/
Polyethylene Glycols
/
Ribavirin
/
Recombinant Proteins
/
Tomography, X-Ray Computed
/
Interferon-alpha
/
Hepatitis C, Chronic
/
Drug Therapy, Combination
/
Republic of Korea
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Clinical and Molecular Hepatology
Year:
2016
Document type:
Article