Hedgehog signaling pathway in chemocarcinogenesis and progression of breast cancer / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 328-332, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-465558
Responsible library:
WPRO
ABSTRACT
The controversial results of several studies suggest that certain everyday-use chemicals may be linked to breast cancer. ln recent years, extensive researches have been carried out to under-stand breast carcinogenesis and the hedgehog(Hh) signaling pathway has emerged as a critical determi-nant of human breast cancer. Aberrant Hh signaling in adults results in carcinogenesis, angiogenesis, and metastasis. This review is focused on the Hh signaling pathway and chemicals in the regulation of breast cancer development and provide an updated survey of pre-clinical and clinical trials of novel strategies to target them.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pharmacology and Toxicology
Year:
2015
Document type:
Article