Immunomodulatory property of Compound Shougong powder on S180 tumor bearing mice / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 7-10, 2015.
Article
in Zh
| WPRIM
| ID: wpr-465816
Responsible library:
WPRO
ABSTRACT
Objective To study the immunomodulatory property of Compound Shougong powder(SGS) on S180 tumor-bearing mice.Methods The S180 model of tumor-bearing mice by Kunming mice were prepared.Then,the tumor-bearing mice were randomized into the model group,positive control group,and SGS groups (29.25g/kg,19.50g/kg,9.75g/kg).Besides the normal group,the other groups were used intragastric administration of into tumor-bearing mice by one time,14 consecutive days.The carbon clearance,quantitative hemolysis and DNFB induced delayed-type hypersensitivity were applied to assay effects of SGS on nonspecific immunity,humoral immunity and cellular immunity.Results Compared with the model control group,in the SGS groups,the tumor-bearing mice with spleen and thymus index of organ improved (all P < 0.05),and the clearance index and values of phagocytic index were elevated(all P <0.05),and the productions of IgM and IgG in serum and hemolysin in splenocytes were enhanced(all P <0.05),and the percentages of T cells expressing CD4+,CD8+ and the ratio of two subset of T lymphocyte increased,and the IL-2 production of spleen lymphocytes was also improved (all P < 0.05).Conclusion SGS showed significant immunomodulatory property on tumor-bearing mice through specific and nonspecific immunity.
Full text:
1
Database:
WPRIM
Type of study:
Clinical_trials
Language:
Zh
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2015
Document type:
Article