Association study of serum HBeAg status and HBV DNA level and hepatic injury in chronic hepatitis B patients / 国际检验医学杂志

ABSTRACT

Objective To explore the associations between different HBeAg staus ,serum HBV DNA level and hepatic injury in patients with chronic hepatitis B (CHB) .Methods HBV DNA level and serum ALT were detected by quantitative Real‐time PCR and velocity methods separately .The degree of hepatic injury was determined by the level of ALT ,and the associations between HBV DNA level and hepatic injury both in HBeAg negative CHB and HBeAg positive CHB patients were analyzed accordingly .Re‐sults Elder age and lower HBV DNA level were found in HBeAg negative CHB patients than in HBeAg positive patients (P0 .05) .Serum HBV DNA level was posi‐tively correlated with the degree of hepatic injury in HBeAg negative CHB patients (P<0 .05) but no similar correlation was found in HBeAg positive patients .Conclusion Positive serum HBeAg is an effective indicator of HBV replication and no correlation is presented between HBV DNA level and intrahepatic inflammation in HBeAg positive CHB patients .However ,HBV DNA level is closely correlated with liver damages in HBeAg negative CHB patients ,more attention should be paid to clinical treatment and fol‐low‐up monitoring of HBeAg negative CHB patients .