Early effects of tumor necrosis factor inhibition on bone homeostasis after soluble tumor necrosis factor receptor use
The Korean Journal of Internal Medicine
; : 807-813, 2014.
Article
in En
| WPRIM
| ID: wpr-46927
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Our aim was to assess whether short-term treatment with soluble tumor necrosis factor (TNF) receptor affects circulating markers of bone metabolism in rheumatoid arthritis (RA) patients. METHODS: Thirty-three active RA patients, treated with oral disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids for > 6 months, were administered etanercept for 12 weeks. Serum levels of bone metabolism markers were compared among patients treated with DMARDs at baseline and after etanercept treatment, normal controls and naive RA patients not previously treated with DMARDs (both age- and gender-matched). RESULTS: Bone-specific alkaline phosphatase (BSALP) and serum c-telopeptide (CTX)-1 levels were lower in RA patients treated with DMARDs than in DMARD-naive RA patients. After 12 weeks of etanercept treatment, serum CTX-1 and sclerostin levels increased. In patients whose DAS28 improved, the sclerostin level increased from 1.67 +/- 2.12 pg/mL at baseline to 2.51 +/- 3.03 pg/mL, which was statistically significant (p = 0.021). Increases in sclerostin levels after etanercept treatment were positively correlated with those of serum CTX-1 (r = 0.775), as were those of BSALP (r = 0.755). CONCLUSIONS: RA patients treated with DMARDs showed depressed bone metabolism compared to naive RA patients. Increases in serum CTX-1 and sclerostin levels after short-term etanercept treatment suggest reconstitution of bone metabolism homeostasis.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Peptides
/
Arthritis, Rheumatoid
/
Time Factors
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Immunoglobulin G
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Biomarkers
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Genetic Markers
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Tumor Necrosis Factor-alpha
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Treatment Outcome
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Bone Remodeling
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Receptors, Tumor Necrosis Factor
Limits:
Adult
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Female
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Humans
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Male
Language:
En
Journal:
The Korean Journal of Internal Medicine
Year:
2014
Document type:
Article