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Expressions of HPV16E6 and E-cadherin in different cervical tissues and its interaction with clinical pathological features / 中国医师杂志
Journal of Chinese Physician ; (12): 995-998, 2015.
Article in Zh | WPRIM | ID: wpr-469453
Responsible library: WPRO
ABSTRACT
Objective To investigate the expressions of human papillomavirus (HPV) 16E6 and E-cadherin in different cervical tissues.Methods Immunohistochemistry expressions of HPV16E6 and E-cadherin were analyzed in 30 normal cervical tissues,34 cervical intraepithelial neoplasias (CIN),and 60 squamous cervical cell carcinomas.Results The differences in positive expression rates of HPV16E6 and E-cadherin were statistically significant among normal cervical tissues,CIN Ⅰ,CIN Ⅱ-Ⅲ,cervical squamous cell carcinomas (x2 =40.166,P =0.000;x2 =31.295,P =0.000),respectively.The abnormal expressions of HPV16E6 and E-cadherin expression were significantly related to clinical pathological stage,tumor size,histological grade,invasion depth of squamous cervical cancers (P < 0.05),but not correlated with age (P >0.05).The expressions between HPV16E6 and E-cadherin protein were negatively correlated (rs =-0.647,P =0.000).Conclusions There may be relationship between HPV16E6 and E-cadherin,and the abnormal expressions of two proteins may be associated with poor prognosis of cervical carcinomas.
Key words
Full text: 1 Database: WPRIM Language: Zh Journal: Journal of Chinese Physician Year: 2015 Document type: Article
Full text: 1 Database: WPRIM Language: Zh Journal: Journal of Chinese Physician Year: 2015 Document type: Article