Association between prostate histologic inflammation classification and prostate cancer in needle biopsy specimens with serum PSA under 20 μg/L / 中华泌尿外科杂志
Chinese Journal of Urology
; (12): 290-293, 2015.
Article
in Zh
| WPRIM
| ID: wpr-470662
Responsible library:
WPRO
ABSTRACT
Objective To investigate the relationship between prostate histologic inflammation classification and prostate cancer (PCa) in needle biopsy specimens with serum prostatic specific antigen (PSA) under 20 μg/L.Methods The clinical records of patients who underwent prostate biopsy were retrospectively analyzed in Beijing Hospital Urological Department from January 2011 to December 2013.The patients underwent prostate biopsy because of PSA raised and without pelvic radiotherapy.The needle biopsy specimen was evaluated by the pathohistologic criteria of location,extent and grade classification of prostate inflammation.Results PCa was detected in 84 (37.2%) biopsies and benign prostatic disease (BPD) in 142 (62.8%) biopsies.There were significant differences between PCa and BPD in inflammation classification (location:P<0.001,extent:P<0.001,grade:P<0.001).On multivariable Logistic regression analysis,both location and extent classification of chronic histologic prostatitis were found tobe significantly associated with a lower risk of PCa in biopsy (location:P =0.001,OR =0.114,95% CI 0.032-0.405 ; extent:P =0.021,OR =0.232,95% CI 0.067-0.804).There was no relationship between grade classification and PCa (P=0.223,OR=1.805,95%CI 0.698-4.667).Under the evaluation of location and extent classification,it could differentiate PCa with BPD in biopsy with a sensitivity,specificity,positive predictive value and negative predictive value of 91.7%,50.7%,52.4%,91.1%,respectively.Conclusion The location and extent classification of chronic prostatitis is found to be associated with a lower risk of PCa independently.
Full text:
1
Database:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Journal of Urology
Year:
2015
Document type:
Article