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The expression level of miR-125a-5p in colorectal cancer with various differentiation / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 801-804, 2014.
Article in Zh | WPRIM | ID: wpr-473103
Responsible library: WPRO
ABSTRACT
Objective To identify the expression level of miR-125a-5p in colorectal cancer (CRC) with various differentiation,and to investigate its diagnostic significance.Methods Real-time polymerase chain reaction was used to analyze the expression level of miR-125a-5p in tumors and paired normal tissues of different differentiated CRC.Receiver-operating-characteristic (ROC) curve was performed to evaluate the specificity and sensitivity of using miR-125a-5p as biomarkers to discriminate CRC patients from normal persons.Results Compared with normal tissues,miR-125a-5p was down-regulated in both high and moderate differentiation,miR-125a-5p could distinguish CRC from normal persons with high sensitivity and specificity,which were 80.00 % and 90.00 %,respectively.Conclusions miR-125a-5p down-regulated in CRC indicates that miR-125a-5p contributes to tumorigenesis,and may be a potential biomarker for CRC.
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Full text: 1 Database: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Cancer Research and Clinic Year: 2014 Document type: Article
Full text: 1 Database: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Cancer Research and Clinic Year: 2014 Document type: Article