Effects of myosin light chain kinase on regulation of endothelial barrier function / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12): 572-576, 2015.
Article
in Zh
| WPRIM
| ID: wpr-474063
Responsible library:
WPRO
ABSTRACT
[ ABSTRACT] Myosin light chain kinase ( MLCK) activates the regulatory light chain of myosin II, and the phos-phorylated myosin light chain leads to actomyosin contractile activity, as well as the cell contraction and increasing intercel-lular gap, which finally results in endothelial barrier dysfunction.MLCK-dependent hyperpermeability occurs in response to multiple cell signaling molecules and signaling pathways, including Ca2+, Src, PKC, NO, cGMP and mitogen activated protein kinases ( MAPK) .In this review, different mechanisms of endothelial hyperpermeability mediated by MLCK are discussed.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Pathophysiology
Year:
2015
Document type:
Article