Clinical characteristics analysis of neonatal thrombocytopenia / 中国综合临床

ABSTRACT

Objective To investigate the cause and clinical characteristics of neonatal thrombocytopenia (NT).Methods A retrospective analysis was performed.71 cases with NT were selected as our subjects.The morbidity of NT was calculated.Results Among the 71 cases with NT,34 were term infants and 37 were preterm infants.The morbidity of NT in preterm infants was significantly higher than that in term infants (x2 =24.56,P ＜0.01).Common causes for NT included intrauterine growth restriction(IUGR),severe asphyxia,severe sepsis or necrotizing enterocolitis (NEC).IUGR was the more frequent cause for early-onset thrombocytopenia than for late-onset thrombocytopenia (x2 =9.20,P =0.002).Severe sepsis or NEC was the more frequent cause for late-onset thrombocytopenia than for early-onset thrombocytopenia (x2 =13.58,P ＜ 0.01).The cases of bleeding in mild thrombocytopenia group was less than that in severe thrombocytopenia group(x2 =5.85,P =0.016).Conclusion IUGR which is the common cause for NT frequently induces earlyonset thrombocytopenia.Severe sepsis or NEC frequently induces late-onset thrombocytopenia accompanied with high bleeding risk.Earlier diagnosis of the cause for NT and tailed treatments can achieve better efficacy.