Assessment for early embryo quality improves the sensitivity and specificity to predicting embryonic development potential / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
; (53): 6849-6855, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-475359
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Embryo viability assessment is directly related to the selection of embryo transplantation and clinical outcome of assisted reproduction.OBJECTIVE:
To summarize the assessment methods for early embryonic development.METHODS:
The first author searched PubMed database for relevant articles published from January 1990 to December 2013 using the keywords of“assisted reproductive technology, art;pre-implantation embryo;embryonic development viability;evaluation methods”in English. Final y, 63 articles were included in result analysis. RESULTS ANDCONCLUSION:
In the embryo quality evaluation, the most widely used method is morphological evaluation method which is characterized as rapid, non-invasive, and simple. With the development of assisted reproductive technology, the morphological evaluation combined with time-lapse imaging analysis system has been recognized in embryo selection. Recently, targeted-metabolic analysis has been proposed as a useful tool for assessment of embryo development potential, involving pyruvate acid, glycometabolism, amino acid, and embryo-derived cytokines (soluble human leukocyte antigen G1, platelet-activating factor, etc.). Furthermore, the pre-implantation genetic screening method targeting gene and chromosome abnormality is expected to find more effective markers for evaluating embryo developmental potential.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
/
Health technology assessment
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2014
Document type:
Article