Different materials for rotator cuff repair augmentation: intensity, degradation rate and acidity degradation products / 中国组织工程研究

ABSTRACT

BACKGROUND:It is unclearwhat kind of material for rotator cuff repair augmentation is the safest or most effective. OBJECTIVE:To review the basic research, clinical application and prospects of materials for rotator cuff repair augmentation. METHODS:Eligible studies were identified from electronic databases including EMbase, Medline, PubMed, OVID, Cochrane Library, Springerlink, CNKI, WanFang, and VIP. RESULTS AND CONCLUSION:There are four kinds of patches used for rotator cuff augmentation tendon patches, non-degradable patches, extracelular matrix-based patches and degradable synthetic patches. Tendon patches have good mechanical strength, but postoperative foreign body reactions and increasing risk of infection and unable to recover the normal structure are problems to be solved. Non-degradable patches also have good mechanical strength, but the long-term safety is unclear. Extracelular matrix-based patches remain a lower mechanical strength and have a higher failure rate. Degradable synthetic patches are proposed to overcome these previous issues by combining wel-adjusted mechanical properties with biological additives and minimize risk of infection by completely absorbing in a time-dependent manner. However, migration of bioactive cels, regulation of degradation rate and suppression of acidic degradation products is are existing problems to be solved.