Risk factors of surgical site infection in patients with colorectal cancer / 中华临床感染病杂志

ABSTRACT

Objective To investigate the incidence and risk factors of surgical site infection ( SSI ) in patients with colorectal cancer .Methods Clinical data of patients with colorectal cancer undergoing surgical treatment in Jiaxing First Municipal People’ s Hospital from October 2011 to December 2014 were retrospectively reviewed.The gender, age, underlying diseases, smoking history, preventive medication, abdominal surgery history , type of surgery , preoperative levels of hemoglobin and albumin , use of laparoscopy, use of stapler, combined organ resection, TNM staging, American Society of Anesthesiologists ( ASA) score was documented .Multivariate logistic regression analysis was performed to identify the risk factors of SSI .Results A total of 773 patients were enrolled in the study , and SSI was observed in 144 cases (18.63%).Multivariate logistic regression analysis showed that use of laparoscopy ( OR =0.35, 95%CI0.15-0.79,P <0.05), use of stapler (OR =0.59, 95% CI 0.39-0.88,P <0.05) were protective factors for SSI, while diabetes (OR=2.11, 95% CI 1.25-3.58,P<0.01), liver cirrhosis (OR=2.12,95%CI1.18-3.79,P<0.05), ASA score (3-4 points) (OR=2.01,95%CI1.20-3.58, P<0.01), combined organ resection (OR=2.17,95% CI1.20-3.92,P<0.05), and anastomotic leak (OR=6.85, 95%CI3.01-15.63,P<0.01) were risk factors for SSI.Conclusions The incidence of SSI is high in patients with colorectal cancer undergoing surgery .Use of laparoscopy and stapler may reduce the incidence of SSI .