Sex chromosomal aneuploidy in spermatozoa of non-hodgkin lymphoma (NHL) patient before therapy

ABSTRACT

Evaluation the ratio of sex chromosomal aneuploidy in NHL patient before therapy spermatozoa by FISH (Fluorescent Insitu Hybridization) technique. Comparison semen of four NHL patients before chemotherapy or irradiation with semen of four controls in the sperm bank. No statistically significant changes in semen in patient group compared to controls. The abnormal ratio with two somatic chromosome 8-8-X or 8-8-Y and diploidy X-Y-8-8 are higher than controls. The rate of aneuploidy in sex chromosome can increase if used in assisted fecundation