Composite Pheochromocytoma or Paraganglioma of Adrenal Gland: A Case Report with Immunohistochemical Studies and Electron Microscopic Examination
Korean Journal of Pathology
; : 306-310, 2011.
Article
in En
| WPRIM
| ID: wpr-47959
Responsible library:
WPRO
ABSTRACT
Composite pheochromocytoma or paraganglioma of the adrenal gland is a well-recognized, yet extremely rare tumor with only one case reported in Korea. We report a case of incidentally found composite pheochromocytoma and ganglioneuroma of the adrenal gland in a 44-year-old female composed of intermingled components of pheochromocytom, ganglioneuroma, and cells with intermediate features. On immunohistochemical staining, the pheochromocytoma component was positive for synaptophysin and chromogranin, but negative for S-100 protein. Staining for the S-100 protein revealed sustentacular cells which formed a peripheral coat around the "Zellballen" and Schwann cells. The Fontana-Masson stain defined neuromelanin granules of ganglion cells and the ganglion cells expressed neural markers such as neurofilament proteins. Ultrastructural findings revealed pheochromocytes with a round or ovoid nucleus and occasionally prominent nucleolus containing numerous adrenaline and noradrenaline granules.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Paraganglioma
/
Pheochromocytoma
/
Schwann Cells
/
Silver Nitrate
/
Epinephrine
/
S100 Proteins
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Norepinephrine
/
Synaptophysin
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Neurofilament Proteins
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Adrenal Glands
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Korean Journal of Pathology
Year:
2011
Document type:
Article