Advances in functions and mechanisms of long non-coding RNA MALAT-1 in tumors / 中国肿瘤临床
Chinese Journal of Clinical Oncology
; (24): 161-165, 2016.
Article
in Zh
| WPRIM
| ID: wpr-487553
Responsible library:
WPRO
ABSTRACT
Long non-coding RNAs (lncRNAs) have gradually become a research hotspot in recent years. The abnormal expression of some lncRNAs has been proven to promote tumorigenesis and progression. Among the lncRNAs, metastasis-associated lung adenocar-cinoma transcript 1 (MALAT-1) has attracted considerable attention in various tumor studies, particularly lung cancer. Therefore, the mechanism in which MALAT-1 regulates the cellular activities of tumors should be analyzed. This review mainly discusses the molecu-lar structure, biological function, and role of MALAT-1 in regulating cell proliferation, tumor metastasis, cell cycle, apoptosis, and so on. Furthermore, the role of MALAT-1 in epigenetic regulation is appropriately illustrated to provide a novel perspective in literature on the prevention and treatment of tumors.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Clinical Oncology
Year:
2016
Document type:
Article