Effects of dexmedetomidine on some hemodynamic indexes and consumption of total intravenous anesthetics of laparoscopic hysterectomy / 中国综合临床

ABSTRACT

Objective To observe the effects of dexmedetomidine on some hemodynamics indexes and the total dosage of propofol and remifentanil of laparoscopic total hysterectomy.Methods Sixty cases patients with total intravenous anesthesia in laparoscopic total hysterectomy were randomly divided into two groups,30 cases in each group.After induction of anesthesia,in the dexmedetomidine group,10 min before anesthesia induction pumping load dexmedetomidine 0.5 μg/kg,and then continue pumped into the maintenance dose of 0.2 μg/(kg · h),stop the medicine in 40 min before the end of operation.The control group were given the same capacity normal saline.The heart rate (HR),systolic blood pressure (SBP),mean arterial pressure (MAP),the total dosage of propofol and remifentanil at different time of before anesthesia(T0),tracheal intubation (T1),beginning of the operation (T2),extubation (T3) were recorded.Results Compared with the control group,hemodynnmic stability(HR,SBP,MAP) of each time of the dexmedetomidine group were better than the control group's,there were statistically significant differences (P＜0.05).The total dosage of propofol,remifentanil of the dexmedetomidine group were (0.11.3 ± 0.013) mg/(kg · min),(0.098 ± 0.009) μg/(kg · min),of the control group were (0.151±0.012) mg/(kg · min),(0.131±0.011) μg/(kg · min),the total dosage of dexmedetomidine group was less than the control group's,there were significant differences(P=0.038,0.045).Conclusion Small dose of dexmedetomidine used in laparoscopic total hysterectomy patients can reduce the total dosage of propofol and remifentanil,more stable hemodynamics at each point,and can be used as a viable programme for clinical application.