The effect of Naa10p on the sensitivity of tongue squamous cell carcinoma Tca8113 cells to pingyangmycin / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 350-353, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-490277
Responsible library:
WPRO
ABSTRACT
Objective:
To study the effect of N-acetyltransferase 10(Naa10p)expression on the sensitivity of tongue squamous cell carcinoma Tca8113 cells to pingyangmycin(PYM).Methods:
The lentiviral vectors of LV-shNaa10p,LV-Naa10p and control LV-NC were transfected into Tca8113 cells,the infection efficiency were identified,then the sensitivity of the infected cells to PYM was determined by MTS assay.Results:
The IC50 of Tca8113-LV-shNaa10p group,Tca8113-LV-Naa10p group and Tca8113-LV-NC group were (20.772 ±0.106)μg/ml,(2.157 ±0.123)μg/ml and (6.301 ±0.069)μg/ml respectively(between groups P <0.05).Con-clusionKnock down of Naa10p may reduce and over expression of Naa10p can increase the sensitivity of Tca8113 cells to PYM.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2016
Document type:
Article