Development of Tim-3 and gastrointestinal tumors / 医学研究生学报
Journal of Medical Postgraduates
; (12): 435-439, 2016.
Article
in Zh
| WPRIM
| ID: wpr-491658
Responsible library:
WPRO
ABSTRACT
As an inhibitory receptor , T cell immunoglobulin mucin domain containing molecules-3 ( Tim-3 ) expresses high levels in the gastrointestinal tumor microenvironment .Tim-3 can promote T cell exhaustion , negatively regulate the anti-cancer immuni-ty of NK cell and induce polarization of macrophages to M 2.Tumor can escape from immunological surveillance through Tim-3.Tim-3 plays an important role in the development and transformation of gastrointestinal tumors .This article summarizes the role of Tim-3 in the gastrointestinal tumors from the aspects of gene polymorphism , T cells, NK cells and mononuclear macrophage .
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Journal of Medical Postgraduates
Year:
2016
Document type:
Article