Study on quality of life and its related factors among patients with chronic hepatitis B / 中华传染病杂志

ABSTRACT

Objective To evaluate the quality of life (QOL ) of chronic hepatitis B (CHB) patients and to explore its related factors .Methods SF‐36 questionnaire was used to evaluate the QOL of 626 CHB patients visited or hospitalized in China‐Japan Friendship Hospital from July 2014 to June 2015 .And the residents around the hospital were included as control group .Sociological characteristics ,clinical data , health related behaviors and nutritional status were collected .Logistic regression analysis was used to analyze the factors related to quality of life . Results Six hundred and twenty‐six participants were enrolled in each group ,including 424 males and 202 females .The average age of CHB group and control group were 44 .2 ± 13 .9 and 44 .2 ± 13 .9 ,respectively .The average QOL score of the CHB patients was 72 .25 ± 16 .06 ,and 8 dimensions and 2 domains of CHB group were lower than those of control group (both P < 0 .05 ) . In multivariate analysis , factors independently associated with higher physical component summary (PCS) score were younger age (18—45 years oldOR=0 .27 ,95% CI0 .13—0 .54 ;45—60 years oldOR= 0 .47 ,95% CI0 .23—0 .95) ,high‐quality sleep (OR= 0 .20 ,95% CI0 .12—0 .33) ,frequent exercise (OR=0 .37 ,95% CI0 .19—0 .73) or occasional exercise (OR=0 .49 ,95% CI0 .30—0 .77) ,and mild hepatitis symptoms (mildOR=0 .19 ,95% CI0 .05 -0 .76 ;moderateOR=0 .20 ,95% CI0 .06—0 .68 ) , while disease duration was associated with lower PCS score ;factor independently associated with higher mental component summary (MCS) score was high quality sleep (OR=0 .25 , 95% CI0 .16—0 .41) ,while longer duration (OR= 14 .04 ,95% CI1 .81—109 .38) and lower weight (OR=2 .72 ,95% CI1 .48—4 .98) were associated with reduced MCS score ( all P<0 .05) .Conclusions The QOL of CHB patients is damaged universally .More attention should be paid to the health related life behavior and nutritional status of CHB patients in the future management .