MiR-126 expression relationship with VEGF in breast cancer and its anti-tumor effect / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 1000-1003, 2016.
Article
in Zh
| WPRIM
| ID: wpr-496534
Responsible library:
WPRO
ABSTRACT
Objective:To probe the expression of miR-126 and VEGF in breast cancer, and the anti-tumor effect of miR-126. Methods:The expression of miR-126 and VEGF in breast cancer tissues and cells were detected by qRT-PCR and Western blot;after transfection with miR-126 mimics into MDA-MB-231,expression of VEGF was detected again,MTT assay and cell scratch test were used to verify the influence of miR-126 on proliferation and migration of tumor cells. Results: The expression of miR-126 was lower in the breast cancer tissues and cells,the expression of VEGF was negative correlation with it,increasing the expression of miR-126 may decrease the expression of VEGF and inhibit the proliferation and migration of breast cancer cells. Conclusion:miR-126 can reduce the proliferation and migration of breast cancer cells by inhibiting the expression of VEGF,which play an anti-tumor effect.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
2016
Document type:
Article