Molecular targeted therapy for hepatocellular carcinoma / 临床肝胆病杂志
Journal of Clinical Hepatology
; (12): 130-134, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-499081
Responsible library:
WPRO
ABSTRACT
Hepatocellular carcinoma (HCC)is the most common malignancy in the liver,for which surgical operation remains the primary treatment.However,the surgical treatment is associated with low resection rate and high recurrence rate,which drive studies on the mole-cule mechanism of initiation,metastasis,and invasion of HCC,in order to develop more effective early diagnosis and treatment methods.By reviewing related literature,this article summarizes the major signaling pathways related to HCC,such as the PI3K/AKT/mTOR signaling pathway,RAS/RAF/MEK/ERK signaling pathway,and VEGF/VEGFR,PDGFR,and FGFR signaling pathway.New advances in the cor-responding molecular targeted therapy for HCC are described,and the perspectives on future direction of relevant research are discussed.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Screening study
Language:
Chinese
Journal:
Journal of Clinical Hepatology
Year:
2015
Document type:
Article